Kadua haupuensis is an extremely rare member of the Rubiaceae family that is endemic to lowland mesic forests on the north face of Mt. Hā'upu, Kaua'i. This species was discovered in 1998 along the base of a cliff on Mt. Hā'upu. The only known population was observed in lowland mesic forest at 1200ft (367m) elevation. The population consisted of seven plants when found. However, by 2005, the plants were extirpated by a landslide and no new individuals have been found despite numerous survey efforts. Kadua haupuensis has been in cultivation since 1999. The source of the ex situ collection is the original set of seeds collected from the original population before it was extirpated. Threats to Kadua haupuensis include but are not limited to feral ungulates (pigs, goats and black tailed deer), predation of fruits and seeds by rats, landslides, nonnative plants and small population size. Conservation efforts are underway on Mt. Hā'upu to remove nonnative species and evaluate the potential for ungulate exclusion fencing. Studies on the reproductive biology K. haupuensis indicate that both females and hermaphrodites are needed at the population level to produce higher quality seeds to support future generations and encourage population stability. Genetic profiling of the plants will provide information about the genetic diversity. This information can be used for selective propagation and potential crossing experiments to enlarge the genetic diversity of propagated plants for future reintroductions and translocations. Provisional seed zones for the island of Kaua'i will be used to guide reintroduction efforts beyond the type locality in order to establish multiple populations which will increase resiliency of the species.