Molecular characterization of highly pathogenic avian influenza viruses h5n6 detected in denmark in 2018–2019
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Molecular characterization of highly pathogenic avian influenza viruses h5n6 detected in denmark in 2018–2019. / Liang, Yuan; Krog, Jesper Schak; Ryt-Hansen, Pia; Pedersen, Anders Gorm; Kvisgaard, Lise Kirstine; Holm, Elisabeth; Nielsen, Pernille Dahl; Hammer, Anne Sofie; Madsen, Jesper Johannes; Thorup, Kasper; Larsen, Lars Erik; Hjulsager, Charlotte Kristiane.
In: Viruses, Vol. 13, No. 6, 1052, 2021.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Molecular characterization of highly pathogenic avian influenza viruses h5n6 detected in denmark in 2018–2019
AU - Liang, Yuan
AU - Krog, Jesper Schak
AU - Ryt-Hansen, Pia
AU - Pedersen, Anders Gorm
AU - Kvisgaard, Lise Kirstine
AU - Holm, Elisabeth
AU - Nielsen, Pernille Dahl
AU - Hammer, Anne Sofie
AU - Madsen, Jesper Johannes
AU - Thorup, Kasper
AU - Larsen, Lars Erik
AU - Hjulsager, Charlotte Kristiane
N1 - Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2021
Y1 - 2021
N2 - Beginning in late 2017, highly pathogenic avian influenza (HPAI) H5N6 viruses caused outbreaks in wild birds and poultry in several European countries. H5N6 viruses were detected in 43 wild birds found dead throughout Denmark. Most of the Danish virus-positive dead birds were found in the period from February to April 2018. However, unlike the rest of Europe, sporadic HPAI H5N6-positive dead wild birds were detected in Denmark in July, August, September, and December 2018, with the last positive bird being found in January 2019. HPAI viruses were not detected in active surveillance of apparently healthy wild birds. In this study, we use full genome sequencing and phylogenetic analysis to investigate the wild bird HPAI H5N6 viruses found in Denmark. The Danish viruses were found to be closely related to those of contemporary HPAI H5N6 viruses detected in Europe. Their sequences formed two clusters indicating that at least two or more introductions of H5N6 into Denmark occurred. Notably, all viruses detected in the latter half of 2018 and in 2019 grouped into the same cluster. The H5N6 viruses appeared to have been maintained undetected in the autumn 2018.
AB - Beginning in late 2017, highly pathogenic avian influenza (HPAI) H5N6 viruses caused outbreaks in wild birds and poultry in several European countries. H5N6 viruses were detected in 43 wild birds found dead throughout Denmark. Most of the Danish virus-positive dead birds were found in the period from February to April 2018. However, unlike the rest of Europe, sporadic HPAI H5N6-positive dead wild birds were detected in Denmark in July, August, September, and December 2018, with the last positive bird being found in January 2019. HPAI viruses were not detected in active surveillance of apparently healthy wild birds. In this study, we use full genome sequencing and phylogenetic analysis to investigate the wild bird HPAI H5N6 viruses found in Denmark. The Danish viruses were found to be closely related to those of contemporary HPAI H5N6 viruses detected in Europe. Their sequences formed two clusters indicating that at least two or more introductions of H5N6 into Denmark occurred. Notably, all viruses detected in the latter half of 2018 and in 2019 grouped into the same cluster. The H5N6 viruses appeared to have been maintained undetected in the autumn 2018.
KW - Birds
KW - Disease outbreaks
KW - Europa
KW - H5N6 subtype
KW - Highly pathogenic avian influenza
KW - Infectious disease outbreak
KW - Influenza A virus
KW - Phylogeny
KW - Surveillance
KW - Wild
U2 - 10.3390/v13061052
DO - 10.3390/v13061052
M3 - Journal article
C2 - 34199456
AN - SCOPUS:85107011816
VL - 13
JO - Viruses
JF - Viruses
SN - 1999-4915
IS - 6
M1 - 1052
ER -
ID: 273370001