Reviewing colchicaceae alkaloids – perspectives of evolution on medicinal chemistry

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Standard

Reviewing colchicaceae alkaloids – perspectives of evolution on medicinal chemistry. / Larsson, Sonny; Rønsted, Nina.

I: Current Topics in Medicinal Chemistry, Bind 14, Nr. 2, 2014, s. 274-289.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Larsson, S & Rønsted, N 2014, 'Reviewing colchicaceae alkaloids – perspectives of evolution on medicinal chemistry', Current Topics in Medicinal Chemistry, bind 14, nr. 2, s. 274-289. https://doi.org/10.2174/1568026613666131216110417

APA

Larsson, S., & Rønsted, N. (2014). Reviewing colchicaceae alkaloids – perspectives of evolution on medicinal chemistry. Current Topics in Medicinal Chemistry, 14(2), 274-289. https://doi.org/10.2174/1568026613666131216110417

Vancouver

Larsson S, Rønsted N. Reviewing colchicaceae alkaloids – perspectives of evolution on medicinal chemistry. Current Topics in Medicinal Chemistry. 2014;14(2):274-289. https://doi.org/10.2174/1568026613666131216110417

Author

Larsson, Sonny ; Rønsted, Nina. / Reviewing colchicaceae alkaloids – perspectives of evolution on medicinal chemistry. I: Current Topics in Medicinal Chemistry. 2014 ; Bind 14, Nr. 2. s. 274-289.

Bibtex

@article{41804f6222df41e69646c556daa95b7e,
title = "Reviewing colchicaceae alkaloids – perspectives of evolution on medicinal chemistry",
abstract = "The subject of chemosystematics has provided insight to both botanical classification and drug development. However, degrees of subjectivity in botanical classifications and limited understanding of the evolution of chemical characters and their biosynthetic pathways has often hampered such studies. In this review an approach of taking phylogenetic classification into account in evaluating colchicine and related phenethylisoquinoline alkaloids from the family Colchicaceae will be applied. Following on the trends of utilizing evolutionary reasoning in inferring mechanisms in eg. drug resistance in cancer and infections, this will exemplify how thinking about evolution can influence selection of plant material in drug lead discovery, and how knowledge about phylogenetic relationships may be used to evaluate predicted biosynthetic pathways",
author = "Sonny Larsson and Nina R{\o}nsted",
year = "2014",
doi = "10.2174/1568026613666131216110417",
language = "English",
volume = "14",
pages = "274--289",
journal = "Current Topics in Medicinal Chemistry",
issn = "1568-0266",
publisher = "Bentham Science Publishers",
number = "2",

}

RIS

TY - JOUR

T1 - Reviewing colchicaceae alkaloids – perspectives of evolution on medicinal chemistry

AU - Larsson, Sonny

AU - Rønsted, Nina

PY - 2014

Y1 - 2014

N2 - The subject of chemosystematics has provided insight to both botanical classification and drug development. However, degrees of subjectivity in botanical classifications and limited understanding of the evolution of chemical characters and their biosynthetic pathways has often hampered such studies. In this review an approach of taking phylogenetic classification into account in evaluating colchicine and related phenethylisoquinoline alkaloids from the family Colchicaceae will be applied. Following on the trends of utilizing evolutionary reasoning in inferring mechanisms in eg. drug resistance in cancer and infections, this will exemplify how thinking about evolution can influence selection of plant material in drug lead discovery, and how knowledge about phylogenetic relationships may be used to evaluate predicted biosynthetic pathways

AB - The subject of chemosystematics has provided insight to both botanical classification and drug development. However, degrees of subjectivity in botanical classifications and limited understanding of the evolution of chemical characters and their biosynthetic pathways has often hampered such studies. In this review an approach of taking phylogenetic classification into account in evaluating colchicine and related phenethylisoquinoline alkaloids from the family Colchicaceae will be applied. Following on the trends of utilizing evolutionary reasoning in inferring mechanisms in eg. drug resistance in cancer and infections, this will exemplify how thinking about evolution can influence selection of plant material in drug lead discovery, and how knowledge about phylogenetic relationships may be used to evaluate predicted biosynthetic pathways

U2 - 10.2174/1568026613666131216110417

DO - 10.2174/1568026613666131216110417

M3 - Journal article

VL - 14

SP - 274

EP - 289

JO - Current Topics in Medicinal Chemistry

JF - Current Topics in Medicinal Chemistry

SN - 1568-0266

IS - 2

ER -

ID: 91832899